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KMID : 0378019840270100083
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New Medical Journal
1984 Volume.27 No. 10 p.83 ~ p.102
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Experimental Studies on the influence of Organophosphorus Pesticides upon the Blood, Kidney and Stomach
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Abstract
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With the progress of farming, raising and foresting, the demand of agricultural pesticide has been remarkably increased, and accordingly, its intoxication has been widely publicized.
Since DDT has been synthesized in 1938, many organic pesticides have been developed with the renovation of pesticide circles. Among these pesticides, organophosphorus chemicals have been believed to be almost nontoxic because they are not accumulative in the tissue. And therefore, organophosphorus chemicals have been used most frequently. However, some studies have reported quite many cases of farmers, cattle feeders and foresters who have been suffered from organophosphorus pesticides, and others have described on the incidence of aggricultural pesticides ranging 20-45% of chemical intoxication. Thus, it has been gradually recognized that the intoxication from organophosphorus pesticide needs to be reviewed.
This study is in this relevance, attempted to examine the effects of organophosphorus pesticide on the blood, kidney and stomach. In doing this, five different organophosphorus pesticides being used frequently in Korea have been selected. And they were divided into normal and experimental groups, and studied hematologically and morphologically.
The results obtained from this experiment are as follows:
1) Serum hemoglobin is decreased´ in the groups of parathion, EPN, DDVP and methyl systox administered in order.
2) Neutrophils are decreased but lymphocytes increased in the groups of parathion, EPN, DDVP administered in order.
3) Blood urea nitrogen is somewhat increased in the groups of parathion and EPN administered in order.
4) Serum creatinine is increased in the groups of parathion, EPN, DDVP and methyl systox administered in order.
5) Serum cholinesterase is significantly suppressed in the groups of parathion, EPN, DDVP, methyl systox and elsan administered in order.
6) Light microscopically, swelling and degeneration of the tubular cells and hyaline casts in the kidney, swelling of the mucosal cells, congestion and areas of inflammatory cell collection in the stomach are observed in the groups of EPN and DDVP administered. In addition, desquamation or necrosis of the tubular cells and hemorrhage of the gastric mucosa are found in the parathion administered groups.
7) Electron microscopically, swelling of mitochondria, partial fragmentation of cristae and electron dense bodies in the kidney, and swelling or ruptured mitochondria and partial detachment of microvilli in the stomach are observed in the groups of EPN and DDVP administered. Additionally, fragmentation of cytoplasmic content, residual bodies and prominent electron dense bodies in the kidney some of which are most likely fat droplets and markedly ruptured mitochondria and partial detachment of microvilli in the stomach are visible in the parathion administered group.
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